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June 2017

Advanced use of Stan, rstan, and Torsten for pharmacometric applications

June 10, 2017 @ 8:30 am - 4:30 pm
Budapest Congress Centr, Jagelló út 1-3
Budapest, Hungary
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Workshop summary: We will provide a guided hands-on experience in the advanced use of Stan, rstan and Torsten for Bayesian PKPD modeling. Stan is a flexible open-source software tool for Bayesian data analysis using Hamiltonian Monte Carlo (HMC) simulation---a type of MCMC simulation. Torsten is a Stan extension containing a library of functions to simplify implementation of PKPD models. This workshop builds on the foundations presented in our previous introductory Stan workshops. Topics include model evaluation and comparison, models with…

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July 2017

Toward Open Science: Translating literature-reported quantitative pharmacology models for simulation and interactive visual exploration

July 20, 2017 @ 11:30 am - 12:30 pm
CIC Cloud City Room, 101 Main Street
Cambridge, MA 02142 United States
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Come learn how we've used public data and powerful open source tools to explore questions in quantitative pharmacology. Lunch will be provided.

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September 2017

QSP Symposium in NYC 2017

September 29, 2017 @ 8:00 am - 5:30 pm
Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue Hess Building
New York, NY 10029 United States
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Please see event website for info. https://www.systems-pharmacology-symposium.com/

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QSP Symposium in NYC 2017

September 29, 2017 @ 8:00 am - 5:30 pm
CIC Cloud City Room, 101 Main Street
Cambridge, MA 02142 United States
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Please see event website for info. https://www.systems-pharmacology-symposium.com/

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October 2017

Advanced use of Stan, rstan, and Torsten for pharmacometric applications

October 15, 2017 @ 8:30 am - 4:30 pm
Marriott Resort: Harbor Beach Hotel, Fort Lauderdale, FL, United States + Google Map

Summary We will provide a guided hands-on experience in the advanced use of Stan, rstan and Torsten for Bayesian PKPD modeling. Stan is a flexible open-source software tool for Bayesian data analysis using Hamiltonian Monte Carlo (HMC) simulation---a type of MCMC simulation. Torsten is a Stan extension containing a library of functions to simplify implementation of PKPD models. This workshop builds on the foundations presented in our previous introductory Stan workshops. Topics include model evaluation and comparison, models with systems of…

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R as a single-step platform for PK/PD and PBPK/QSP M&S: integration of model estimation, optimization, simulation, and reporting

October 19, 2017 @ 8:30 am - 5:00 pm
Marriott Resort: Harbor Beach Hotel, Fort Lauderdale, FL, United States + Google Map

Summary We’ll introduce the concept of a single platform for modeling and simulation using R. After a brief refresher on basic mrgsolve use (an R package for simulation from ODE-based PKPD and QSP models), we will lead you through case studies reflecting real-world modeling and simulation workflows. The hands-on examples will focus on planning, executing, and presenting simulation-based answers to questions in drug development. Workshop examples will include: exploring study designs by interfacing mrgsolve with the optimal design package PopED…

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January 2018

StanCon 2018

January 10 - January 12

Metrum Research Group is proud to be a sponsor for StanCon 2018: Three days of talks, open discussions, and statistical modeling. We hope to see you there!  

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rstudio::conf

January 31 @ 8:00 am - February 3 @ 5:00 pm

Look for Metrum Research Group's exhibit booth at the rstudio conference! Stop by to say hello, tell us about the projects you are working on, and check out Metworx. rstudio::conf is about all things R and RStudio! Join hundreds of advanced and new R users in San Diego, CA, January 31 to February 3, 2018 to become better at data science with R – and have some fun along the way!

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February 2018

University of Minnesota Advanced R Workshop with Metrum Research Group

February 24 @ 1:00 pm - 5:00 pm

University of Minnesota Advanced R Workshop with Metrum Research Group Date: February 24 - March 10, 2018 (Three consecutive Saturdays) Time: 1 pm - 5 pm The University of Minnesota Department of Experimental and Clinical Pharmacology, in collaboration with Metrum Research Group and the ISoP Student Leadership Committee, will present a series of three tutorial sessions on applied simulation and model visualization with the mrgsolve package for R.  It is expected that participants will be comfortable programming basic data analysis tasks in R…

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March 2018

Case studies with mrgsolve: PBPK and QSP model implementation and utilization in R

March 24 @ 1:30 pm - 5:30 pm
UF School of Pharmacy, 6550 Sanger Road
Orlando, FL 32827 United States
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In this tutorial session, we will review case studies in PBPK and QSP modeling and simulation using mrgsolve in R.  mrgsolve (https://mrgsolve.github.io) is a free, open-source modeling and simulation platform to support ODE-based model development in R. Outline: mrgsolve overview (brief tutorial) PBPK model characterizing drug-drug interactions between HMG-CoA reductase inhibitors and cyclosporine (Yoshikado et al. 2016; PMID 27170342) Sensitivity analyses Parameter estimation Evaluation of combination chemotherapy regimens using a QSP model for MAP kinase signaling in colorectal cancer (Kirouac…

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