Dan joined Metrum in September, 2010 and is an applied statistician with an emphasis on Bayesian biostatistics, clinical trial design, and high performance statistical computing. His dissertation topic was adaptive design for heterogeneous time-to-event data in a Bayesian decision theory framework.
Dan Polhamus, Jonathan French, Shang-Chiung Chen, Bei Wang, Chunze Li, Dan Lu, Sandhya Girish, Jin Jin, Angelica Quartino. A Modeling and Simulation Framework for Exposure-Response Analysis in Oncology: Com- parison and Considerations of Multiple Methodologies. ACoP 6. October 2015.
Dan Polhamus, Jonathan L. French. Assessment of propensity score and Mahalanobis distance matching in the exposure-response setting. PAGE 2015.
Daniel G. Polhamus, Jia Kang, James A. Rogers, and Marc R. Gastonguay. Web-based Software for Real-time Simulation-assisted Trial Design in Alzheimer’s Disease. CTAD 2014.
Knebel W, Rogers J, Polhamus D, Ermer J, Gastonguay MR. Modeling and simulation of the exposure-response and dropout pattern of guanfacine
extended-release in pediatric patients with ADHD. J Pharmacokinet Pharmacodyn. 2014 Nov 6.
Angelica Quartino, Dan Polhamus, James Rogers, and Jin Jin. An integrated natural disease progression model of nine cognitive and biomarker endpoints in patients with Alzheimer’s Disease. PAGE 2014. Abstr 3187.
Daniel G. Polhamus, Ph.D., James A. Rogers, Ph.D., William R. Gillespie, Ph.D., Jonathan French, Sc.D. Clinical Dementia Rating Modeling and Simulation: Joint progression of CDR and biomarkers in the ADNI cohort. AAIC 2013.
Timothy Bergsma, William Knebel, Daniel Polhamus, Jeffrey T. Hane, Marc R. Gastonguay. A Cloud-Based Cluster Computing Platform for Pharmacometric Applications. ACoP 2013.
Jorge Luiz Gross, James Rogers, Daniel Polhamus, William Gillespie, Christian Friedrich, Yan Gong, Brigitta Ursula Monz, Sanjay Patel, Alexander Staab, Silke Retlich. A novel model-based meta-analysis to indirectly estimate the comparative efficacy of two medications: an example using DPP-4 inhibitors, sitagliptin and linagliptin, in treatment of type 2 diabetes mellitus. BMJ Open. 5 March 2013.
William Knebel, Jim Rogers, Dan Polhamus, Sharon Youcha, Carla White, Jim Ermer, and Marc Gastonguay. Modeling and Simulation of Guanfacine Extended-Release to Support Pediatric Trial Design. American Academy of Child and Adolescent Psychiatry, 59th Annual Meeting. 2012.
Rogers JA, Polhamus D, Gillespie WR, Ito K, Romero K, Qiu R, Stephenson D, Gastonguay MR, Corrigan B. Combining patient-level and summary-level data for Alzheimer’s disease modeling and simulation: a beta regression meta-analysis. J Pharmacokinet Pharmacodyn. October 2012, Volume 39, Issue 5, pp 479-498.
James Rogers, Peter Lockwood, Dan Polhamus, Yves Brault, Anne Desmet, Kaori Ito, Klaus Romero, Ruolun Qiu, Bill Gillespie, Brian Corrigan, Marc Gastonguay. Model-based Analysis to Support Strategic Decision Making: A Case Study from the Development of a 5HT6 Antagonist for the Treatment of Alzheimer’s Disease.
Jorge L. Gross, James Rogers, Dan Polhamus, William Gillespie, Sanjay Patel, Christian Friedrich, Yan Gong, Brigitta Monz, Alexander Staab, Silke Retlich. Novel Model-based Meta-Analysis to Estimate comparative Efficacies of 2 Drugs: an Example Using the DPP-4 inhibitors Linagliptin and Sitagliptin in Type 2 Diabetes Mellitus. American Diabetes Association 72nd Scientific Sessions (2012).
James Rogers, Dan Polhamus, William Gillespie, Christian Friedrich, Alexander Staab, and Silke Retlich. Model-based Meta-analysis Comparison of the Effects of Linagliptin and Sitagliptin on HbA1c Levels in Patients with Type 2 Diabetes Mellitus. PAGE 21 (2012).
Dan Polhamus, Jim Rogers, Bill Gillespie, Jonathan French, and Marc Gastonguay. From Evidence Synthesis to Trial Optimization: The adsim Package for Model-based Simulation in Alzheimer’s Disease. PAGE 21 (2012).
Rogers J, Polhamus D, Ito K, Qiu R, Gillespie B, Corrigan B. The Value of Evidence Synthesis: Model-based Meta-analysis Based on the CAMD Database, the ADNI AD Cohort Data, and Literature Meta-data. 2012.
Polhamus, D, Baron KT, Purohit, VS, Ravva P, Rogers, JA, Gastonguay MR. A Time to Event Approach for Standard of Care Meta-Analysis in HCV Trials. Presented at ACOP 2011, San Diego, CA