Bill joined MetrumRG in 2004, where he was appointed President of Strategic Modeling & Simulation in 2016 after serving most recently as Principal Scientist II and Group Leader of the Pharmacology Modeling & Simulation Team. Bill has worked extensively in applying mathematical modeling and simulation techniques to optimize drug development across both academic and industrial settings. In his 12 years at MetrumRG, Bill has taken a leadership role in strengthening our team’s capabilities and has been a champion of applying high-performance cloud computing environments to facilitate problem solving in drug development.
Knebel W, Rogers J, Polhamus D, Ermer J, Gastonguay MR. Modeling and simulation of the exposure-response and dropout pattern of guanfacine
extended-release in pediatric patients with ADHD. J Pharmacokinet Pharmacodyn. 2014 Nov 6.
Population Pharmacokinetic (PPK) Modelling and Simulation to Support Pediatric Dose Selection of Ceftaroline Fosamil (CPT-F) in Children Aged 28 Days to 12 Years. T Khariton, T Riccobene, W Knebel, T O’Neal, P Ghahramani, ACOP5 2014.
W. Knebel, J. Ermer, J. Purkayastha, P. Martin, and M. R. Gastonguay. Population pharmacokinetic/pharmacodynamic modeling of guanfacine effects on QTc and heart rate in pediatric patients. AAPS J, Aug 2014.
Timothy Bergsma, William Knebel, Daniel Polhamus, Jeffrey T. Hane, Marc R. Gastonguay. A Cloud-Based Cluster Computing Platform for Pharmacometric Applications. ACoP 2013.
Knebel W, Gastonguay MR, Malhotra B, El-Tahtawy A, Jen F, Gandelman K. Population Pharmacokinetics of Atorvastatin and Its Active Metabolites in Children and Adolescents With Heterozygous Familial Hypercholesterolemia: Selective Use of Informative Prior Distributions from Adults. J Clin Pharmacol. Feb 4, 2013 [Epub ahead of print].
Bergsma TT, Knebel W, Fisher J, Gillespie WR, Riggs MM, Gibiansky L, Gastonguay MR. Facilitating pharmacometric workflow with the metrumrg package for R. Comput Methods Programs Biomed. 2013 Jan;109(1):77-85.
William Knebel, Jim Rogers, Dan Polhamus, Sharon Youcha, Carla White, Jim Ermer, and Marc Gastonguay. Modeling and Simulation of Guanfacine Extended-Release to Support Pediatric Trial Design. American Academy of Child and Adolescent Psychiatry, 59th Annual Meeting. 2012.
Knebel W, Rao N, Uchimura T, Mori A, Fisher J, Gastonguay MR, Chaikin P. Population pharmacokinetic-pharmacodynamic analysis of istradefylline in patients with Parkinson disease. J Clin Pharmacol. 2012 Oct;52(10):1468-81.
Bergsma TT, Knebel W, Fisher J, Gillespie WR, Riggs MM, Gibiansky L, Gastonguay MR. Facilitating pharmacometric workflow with the metrumrg package for R. Comput Methods Programs Biomed. 2012 Sep 28.
Cirrincione-Dall G, Gastonguay MR, Knebel, W, Bergsma T, Zhang AY, Patel D, Barrett JS, van Schaik R, Soldin OP, Soldin SJ, Nulmin I, Koren G, de Wildt SN. A Population Pharmacokinetic Model of Tacrolimus in Pediatric Liver Transplant Recipients. Presented at ACOP 2011, San Diego, CA.
Bergsma T, Fisher J, Gastonguay MR, Hane J, Knebel W, Riggs MM, Rogers JA. Systematic Review of Versioned Files for Modeling and Simulation Quality Control: The“review” R Package. Presented at ACOP 2011, San Diego, CA.
Knebel W, Tammara B, Udata C, Comer G, Gastonguay MR, Meng X. Population pharmacokinetic modeling of pantoprazole in pediatric patients from birth to 16 years. J Clin Pharmacol. 2011 Mar;51(3):333-45.
Knebel W, Rao N, Uchimura T, Mori A, Fisher J, Gastonguay MR, Chaikin P. Population pharmacokinetic analysis of istradefylline in healthy subjects and in patients with Parkinson’s disease. J Clin Pharmacol. 2011 Jan;51(1):40-52.
Knebel W, Bergsma TT, Dagdigian C, Hane J, Gastonguay MR. Utilizing NONMEM 7 and the Intel Fortran Compiler in a Distributed Computing Environment. PAGE 2010.
Nathanael Dirks, Marc R. Gastonguay, William R. Gillespie, William Knebel, Matthew M. Riggs, John C. Panetta, and Bernd Meibohm. Comparative Performance of Bayesian Markov Chain Monte Carlo and Maximum Likelihood Population Estimation Methods when Applied to Nonlinear Pharmacokinetics of Monoclonal Antibodies. Presented at ASCPT 111th Annual Meeting, March 17-20, 2010
Timothy Bergsma, Jeffrey Hall, Michael S. Smith, Malaz A. AbuTarif, David R. Taft, William Knebel, Joseph Hebert, James Rogers, Jeffrey T. Hane, and Marc R. Gastonguay. Development and Pilot Evaluation of a High-Performance Computing System for Web-Based Deployment of Pharmacometrics Applications in a Multi-User Training Environment. ACOP 2009.
Nicholas T, Knebel W, Gastonguay MR, Bednar MM, Billing B, Landen JW, Kupiec JW, Corrigan B, Laurencot R, Zhao Q. Preliminary population pharmacokinetic modeling of PF-04360365, a humanized anti-amyloid monoclonal antibody, in patients with mild-to-moderate Alzheimer’s disease. ICAD 2009.
Knebel W, Palmen M, Dowell JA, Gastonguay M. Population pharmacokinetic modeling of epoetin delta in pediatric patients with chronic kidney disease. J Clin Pharmacol. 2008 Jul;48(7):837-48.
Knebel W, Bergsma T, Fisher J, Georgalis G, Gibiansky L, Gillespie WR, Riggs MM, and Gastonguay MR. Facilitating the Pharmacometrics Work-Flow with the MItools R Package. American Conference on Pharmacometrics, 2008.
Gillespie WR, Gastonguay MR, Knebel W, Georgalis G. Open Source Software Tools for Parallel Computation of Multiple MCMC Chains with WinBUGS. American Conference on Pharmacometrics, 2008.
Fisher J, Gastonguay MR, Knebel W, Gibiansky L, Wire MB. Population Pharmacokinetic Modeling of Fosamprenavir in Pediatric HIV-Infected Patients. American Conference on Pharmacometrics, 2008.
W.R. Gillespie, M.R. Gastonguay, W. Knebel. Bayesian Approaches to Mixed Effects Models for Ordered Categorical Data. AAPS Annual Meeting, San Diego, November 2007.
Knebel W, Rao N, Bergsma T, Gastonguay M, Mori A, Uchimura T, Allenby K, Dvorchik B, Sussman N, Chaikin P. Population Pharmacokinetic-Pharmacodynamic Modeling of Istradefylline in Patients With Parkinson’s Disease. ACCP 2007.
Knebel B, Bergsma T, Gibiansky L, Hane JT, Gastonguay MR. NMQual: A Tool to Automate Installation and Facilitate Qualification of NONMEM. PAGE Annual Meeting: Abstracts, 2005.