Meet the Team

Marc R. Gastonguay, Ph.D.


For the last 20 years, Marc has been applying mathematical M&S techniques to problems in clinical pharmacology and drug development across industrial, government, and academic settings. Marc provides the scientific and thought leadership for MetrumRG.

Jeffrey T. Hane, Ph.D.


Jeff has extensive experience in pharma (20+ years) that includes regulatory compliance, quality assurance, discovery R&D, and technical operations. He focuses on cloud computing technologies (IaaS, code-managed architectures, transformation of legacy workflows) and their applications to biomedical modeling and simulation. He is also interested in any technology that streamlines the company’s scientific or business processes. Jeff directs the information systems and business operations for MetrumRG.

William Knebel, Pharm.D., Ph.D.

President, Strategic Modeling and Simulation

Bill joined MetrumRG in 2004, where he was appointed President of Strategic Modeling & Simulation in 2016 after serving most recently as Principal Scientist II and Group Leader of the Pharmacology Modeling & Simulation Team. Bill has worked extensively in applying mathematical modeling and simulation techniques to optimize drug development across both academic and industrial settings. In his 12 years at MetrumRG, Bill has taken a leadership role in strengthening our team’s capabilities and has been a champion in applying high-performance could computing environments to facilitate problem solving in drug development.

William R. Gillespie, Ph.D.

Vice President, Strategic Modeling and Simulation

For over 20 years Bill has been involved in the development and application of pharmacometric methodology for enhancing drug treatment, development and regulation. His current interests include the use of Bayesian modeling and simulation to optimize decision-making in clinical drug development and treatment. He plans to make Bayesian modeling and simulation methods more accessible via training programs and development of software tools.

Matthew M. Riggs, Ph.D.

Fellow and Group Leader, Systems Pharmacology M&S

Matt offers 12 years of industry experience including the application of modeling and simulation for clinical pharmacology and later phase drug development decisions. Matt’s interests include the development and application of mechanistic exposure-response and systems pharmacology models to quantitatively integrate physiology, pharmacology, senescence and disease understandings; this to guide translational and clinical research toward improved preventative and interventional therapeutics.

James A. Rogers, Ph.D.

Principal Scientist II, Group Leader

Jim Rogers has over 15 years of experience as an applied statistician in the biomedical industry. He currently holds the title of Principal Scientist II at Metrum Research Group, where he leads a team of statistical modeling and simulation scientists. Prior to joining Metrum Research Group, Jim was an Associate Director of Statistics at Pfizer Global Research and Development, where he was the statistical lead on numerous clinical and preclinical projects in neuroscience. In 2008, Jim joined Metrum Research Group in order to work in closer collaboration with quantitative biologists and pharmacometricians. From a methodological perspective, Jim has been especially active in longitudinal modeling of constrained responses (e.g. cognitive rating scales in neuroscience), simulation-assisted design of dose-ranging trials and trials with adaptive features, and technologies for dynamic / interactive statistical support.

Jonathan French, Sc.D.

Principal Scientist II, Director of Innovation

Jonathan has over 10 years of drug development experience. He began his career as a project statistician; designing, analyzing and interpreting clinical trials in depression and ADHD. His primary areas of expertise range from model-based meta-analysis and applied Bayesian methods to modeling time-to-event data and missing data mechanisms.

CJ Godfrey, Ph.D.

Principal Scientist II and Director, MetroBoston

CJ has 16 years of drug development experience in both pharma and consulting roles and has been applying pharmacometric methods to PK/PD/outcome analysis and decision support for 20 years. His clinical experience spans a broad range of biomarker, safety, and efficacy endpoints with particular emphasis on oncology, inflammation, and viral diseases. He has extensive experience in performing model-based meta-analyses and near-real-time population PK/PD modeling to support informed and timely decision making.

John T. Mondick, Ph.D.

Principal Scientist

John has 5 years of experience in the pharmaceutical industry and academia applying modeling and simulation to problems in clinical pharmacology. John’s interests include the application of modeling and simulation in pediatric pharmacology and the development of mechanistic models to optimize decision making in drug development.

Scott Pivirotto

Senior Scientist II, Group Leader

Scott comes to Metrum with over 15 years of experience within the pharmaceutical industry. Having worked in database development, data management, and programming support for modeling and simulation analyses and global safety reporting, he has supported all phases of drug development across multiple therapeutic areas. He is keenly interested in data base design, data aggregation, and data scrubbing as they pertain to data mining and analysis needs.

Kyle T. Baron, Pharm.D., Ph.D.

Senior Scientist

Kyle Baron joined MetrumRG in 2010 as a Research Scientist, working with the systems biology group to develop Bayesian hepatitis C viral dymanic models to help quantify antiviral drug effects and predict long-term viral response rates.

Nathanael L. Dirks, Pharm.D., Ph.D.

Senior Scientist

Nathanael joined Metrum in March 2010 after receiving his Pharm.D. and Ph.D. (Pharmaceutical Sciences) from the University of Tennessee Health Science Center. His dissertion topic was population PK-PD modeling of therapeutic monoclonal antibodies with an application of Bayesian and maximum likelihood estimation methods. In recent years, he has worked on modeling and simulation projects for both small molecule and biologic therapeutics in areas of pediatric pharmacology, pain management, hypertension, asthma, Crohn’s disease, and ulcerative colitis. His interests also include teaching and developing training material related to basic PK-PD concepts and prinicples of modeling and simulation.

Jeannine M. Fisher, M.S.


Jeannine joined Metrum in 2006 and has more than 20 years of experience in basic pharmaceutical and clinical research experience in academia and the pharmaceutical industry. Jeannine has supported all phases of clinical research across multiple therapeutic areas, with a particular emphasis on drug development in pediatric and rare disease patient populations.

Daniel G. Polhamus, Ph.D.

Senior Scientist, Statistics

Dan joined Metrum in September, 2010 and is an applied statistician with an emphasis on Bayesian biostatistics, clinical trial design, and high performance statistical computing. His dissertation topic was adaptive design for heterogeneous time-to-event data in a Bayesian decision theory framework.

Jayson D. Wilbur, Ph.D.

Senior Scientist, Statistics

Jayson is an experienced statistician who joined Metrum in 2014 after working for several years on problems in diagnostic medicine and public health in both industrial and academic settings. His primary areas of statistical expertise are multivariate analysis, Bayesian modeling and methods for evaluation of diagnostic tests.

Lonni Schulz, M.S.

Research Scientist

With Master’s degrees in both computer & information science and applied genomics, Lonni joined Metrum in 2014. She brings 12 years of pharmaceutical industry experience in clinical and pre-clinical environments to the challenges of data set assembly and data programming.

Jia Kang, Ph.D.

Research Scientist

Jia joined MetrumRG in 2013 as a Research Scientist. Her research interests are focused on modeling and simulation in pharmacokinetics and pharmacodynamics, and model-based meta-analysis using a Bayesian framework.

Curtis K. Johnston, Pharm.D.

Research Scientist

Curtis joined Metrum in 2014 after receiving his Pharm.D. from the University at Buffalo and completing a clinical PK/PD Fellowship through UNC Chapel Hill/Quintiles. His clinical experience includes infectious disease (bacterial), oncology, and chronic liver disease (HCV and NASH). Curtis’s research interests include Bayesian methodology and the application of M&S to help inform drug development decisions.

Rena J. Eudy, Ph.D.

Research Scientist

Rena joined Metrum in November 2015 after completing her Ph.D. in Biomedical Engineering at the University of Connecticut. Her dissertation work included extending a systems pharmacology model of bone and osteoporosis to be relevant for the development new therapies. Part of this work included linking simulated changes in bone mineral density to a hazard model of fracture in a Bayesian framework in order to predict the probability of fracture in osteoporosis patients. Analysis tools for establishing a priori identifiability of target-mediated drug disposition and other indirect response-type models were also part of this larger work. Rena brings 5 years of industry experience to the team, including work in preclinical development in metabolic systems and neuroscience and using systems pharmacology models to inform clinical decisions.

Ramon I. Garcia, Ph.D.

Research Scientist, Statistics

Ramon joined Metrum in January 2017. He obtained his Ph.D. in Biostatistics from the University of North Carolina where his dissertation topic was "variable selection in models with missing data using a Bayesian framework". Ramon did research at the EPA where he investigated identifiability and estimation of physiologically based pharmacokinetic models. Ramon's interests include model selection and estimation of nonlinear mixed effects models and Bayesian analysis of pharmacokinetic models.

Alanna S Ocampo-Pelland, Ph.D.

Research Associate

Alanna joined Metrum in October 2016 after completing her Ph.D. in Biomedical Engineering at the University of Connecticut. Her dissertation work included model-based meta-analysis for developing a population pharmacokinetic model to compare the dispositions of Vitamin D2, D3 and their 25-hydroxylated metabolites in healthy and osteoporotic patients. Extension of this work included linking 25OHD exposure to changes in bone-markers and bone mineral density, following Vitamin D doses commonly given as background therapy in osteoporosis drug trials. She is currently pursuing a postdoctoral position at Metrum, researching optimal modeling methods for analyzing tumor-size data from basket trials for cancer therapies aimed at specific genetic markers across a wide range of histologies.

Jonathan Sidi

Research Associate

Jonathan is an experienced statistician who joined Metrum in 2016 after working for several years on problems in applied statistics, financial stress testing and economic forecasting in both industrial and academic settings. He holds a double major in Statistics and Economics, and a Masters of Statistics from the Hebrew University of Jerusalem. He is currently pursuing a PhD in Statistics at the Hebrew University of Jerusalem, focusing on signal process classification and monitoring in a high dimension setting. His primary areas of statistical expertise are generalized mixed effects models, dimension reduction, multivariate statistical process monitoring and machine learning.

Charles Margossian

Pharmacometrics Bootcamp Scientist

Charles joined Metrum in 2015 after obtaining a B.Sci from Yale University and brings with him two years of data mining experience applied to astrophysics. His current focus is on the application of differential geometry and mathematical physics to Bayesian statistics. The software he develops are aimed at facilitating the use of these techniques in pharmacometrics.

James S. Marsan

Development and Resourcing Director

Jim has over 20 years experience spanning multiple disciplines including sales, sales operations, business development, contract negotiations, and project management. Jim oversees all contract negotiations and interfaces with Metrum scientists and executive management to ensure timely delivery of all project deliverables.

Michelle Johnson

Director of Strategic Marketing

Michelle brings over 12 years of Marketing and Management experience from a variety of industries including Media and Athletics to her current role as Strategic Marketing Director here at Metrum. With an MBA from Babson College, she has extensive training and practical experience in entrepreneurial business strategy and market positioning. Michelle is driven by a creative approach to communications and aims to understand and advocate for the voice of our customers. She is often the first point of contact here at Metrum, so feel free to contact her directly if you are interested in our services and solutions.

Matthew Parr

AWS and DevOps Engineer

Matt brings over 8 years of DevOps experience to Metrum, where he joined in 2017 to oversee all electronic assets at the company. He has several Amazon Web Services (AWS) certifications, and he has worked extensively with AWS cloud services and infrastructure since its inception. Prior to joining Metrum, Matt was instrumental in the architecture, implementation, and management of the cloud infrastructure for Harvard Business School’s HBX online learning platform. Matt has also worked as an independent consultant providing cloud and DevOps solutions to clients.

Heidi Seaborg

Client Relationship Manager

Heidi initially served Metrum in 2006 as a technical writer, and she returned in 2016 to lead client communications. She facilitates all contract negotiations and liaises between Metrum scientists and clients during the proposal process. Prior to rejoining Metrum, she handled contracts and planned conferences for a private research firm that funds neurodegeneration research.

Diane Reynolds

Office Administrator

With more than two decades of senior office administration and financial management experience, Diane brings an array of administrative expertise to Metrum. She provides contract support, manages event logistics, and handles scheduling and office administration for the company. Diane joined Metrum in 2015, having previously served as the business manager for a not-for-profit organization, a radio broadcasting group and an international tea company.