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R as a single-step platform for PK/PD and PBPK/QSP M&S: integration of model estimation, optimization, simulation, and reporting
Summary We’ll introduce the concept of a single platform for modeling and simulation using R. After a brief refresher on basic mrgsolve use (an R package for simulation from ODE-based PKPD and QSP models), we will lead you through case studies reflecting real-world modeling and simulation workflows. The hands-on examples will focus on planning, executing, and presenting simulation-based answers to questions in drug development. Workshop examples will include: exploring study designs by interfacing mrgsolve with the optimal design package PopED…Find out more
Metrum Research Group is proud to be a sponsor for StanCon 2018: Three days of talks, open discussions, and statistical modeling. We hope to see you there!Find out more
Look for Metrum Research Group's exhibit booth at the rstudio conference! Stop by to say hello, tell us about the projects you are working on, and check out Metworx. rstudio::conf is about all things R and RStudio! Join hundreds of advanced and new R users in San Diego, CA, January 31 to February 3, 2018 to become better at data science with R – and have some fun along the way!Find out more
University of Minnesota Advanced R Workshop with Metrum Research Group Date: February 24 - March 10, 2018 (Three consecutive Saturdays) Time: 1 pm - 5 pm The University of Minnesota Department of Experimental and Clinical Pharmacology, in collaboration with Metrum Research Group and the ISoP Student Leadership Committee, will present a series of three tutorial sessions on applied simulation and model visualization with the mrgsolve package for R. It is expected that participants will be comfortable programming basic data analysis tasks in R…Find out more
In this tutorial session, we will review case studies in PBPK and QSP modeling and simulation using mrgsolve in R. mrgsolve (https://mrgsolve.github.io) is a free, open-source modeling and simulation platform to support ODE-based model development in R. Outline: mrgsolve overview (brief tutorial) PBPK model characterizing drug-drug interactions between HMG-CoA reductase inhibitors and cyclosporine (Yoshikado et al. 2016; PMID 27170342) Sensitivity analyses Parameter estimation Evaluation of combination chemotherapy regimens using a QSP model for MAP kinase signaling in colorectal cancer (Kirouac…Find out more
Join us for a guided hands-on experience in the advanced use of Stan, rstan, and Torsten for Bayesian PKPD modeling.
Topics include: model evaluation and comparison, models with systems of ODEs, optimizing Stan code, using MCMC results for population and trial simulations, and much more!
You will execute Bayesian data analysis examples using Stan. Via the examples, you will learn to implement population PKPD models including those involving censoring, numerical solution of ODEs, and user-defined probability distributions and likelihoods.
We will provide a guided hands-on experience in the use of the R package mrgsolve. mrgsolve is a free, open source, validated R package to facilitate simulation from hierarchical, ODE-based PK/PD and systems pharmacology models frequently employed in pharmaceutical research and development programs. You will code, execute, and summarize PK, PK/PD and systems pharmacology model simulations using mrgsolve and R. Through many examples, you will learn to implement model-based simulations to help address questions at a variety of stages of a development program.Find out more
This 1.5 day workshop will be held at Cambridge Innovation Center (101 Main St Cambridge, MA) June 6, 2018 1:00 pm - 5:30 pm June 7, 2018 9:00 am - 5:00 pm Course Instructors: Ahmed Elmokadem, Ph.D., Kyle Baron, Pharm.D., Ph.D., Matthew Riggs, Ph.D., Marc R Gastonguay, Ph.D. Summary This hands-on workshop will provide participants with a technical foundation for physiologically-based pharmacokinetic (PBPK) model development in R using mrgsolve, a free, open-source modeling and simulation platform for ODE-based model development…Find out more
We will provide a guided hands-on experience in the use of Stan (http://mc-stan.org/), rstan (http://mc-stan.org/interfaces/rstan.html), rstanarm (http://mc-stan.org/users/interfaces/rstanarm.html) and Torsten (https://github.com/metrumresearchgroup/example-models) for Bayesian analysis of categorical, count and time-to-event data. Stan is a flexible open-source software tool for Bayesian data analysis using Hamiltonian Monte Carlo (HMC) simulation---a type of MCMC simulation. Torsten is a Stan extension containing a library of functions to simplify implementation of PKPD models. This workshop builds on the foundations presented in our previous introductory Stan workshops (https://www.metrumrg.com/course/brief-introduction-bayesian-modeling-using-stan/).…Find out more
This hands-on workshop will provide participants with a technical foundation for physiologically-based pharmacokinetic (PBPK) model development in R using mrgsolve, a free, open-source modeling and simulation platform for ODE-based model development in R (https://mrgsolve.github.io). The workshop gets started with an introduction to simulation with mrgsolve. We'll cover the essentials of a tidy simulation workflow in R. Then we'll jump into PBPK modeling with mrgsolve. After a brief introduction to principles of PBPK, we'll work through case studies using PBPK modeling.…Find out more
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