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Join us for a guided hands-on experience in the advanced use of Stan, rstan, and Torsten for Bayesian PKPD modeling.
Topics include: model evaluation and comparison, models with systems of ODEs, optimizing Stan code, using MCMC results for population and trial simulations, and much more!
You will execute Bayesian data analysis examples using Stan. Via the examples, you will learn to implement population PKPD models including those involving censoring, numerical solution of ODEs, and user-defined probability distributions and likelihoods.
We will provide a guided hands-on experience in the use of the R package mrgsolve. mrgsolve is a free, open source, validated R package to facilitate simulation from hierarchical, ODE-based PK/PD and systems pharmacology models frequently employed in pharmaceutical research and development programs. You will code, execute, and summarize PK, PK/PD and systems pharmacology model simulations using mrgsolve and R. Through many examples, you will learn to implement model-based simulations to help address questions at a variety of stages of a development program.Find out more
This 1.5 day workshop will be held at Cambridge Innovation Center (101 Main St Cambridge, MA) June 6, 2018 1:00 pm - 5:30 pm June 7, 2018 9:00 am - 5:00 pm Course Instructors: Ahmed Elmokadem, Ph.D., Kyle Baron, Pharm.D., Ph.D., Matthew Riggs, Ph.D., Marc R Gastonguay, Ph.D. Summary This hands-on workshop will provide participants with a technical foundation for physiologically-based pharmacokinetic (PBPK) model development in R using mrgsolve, a free, open-source modeling and simulation platform for ODE-based model development…Find out more
We will provide a guided hands-on experience in the use of Stan (http://mc-stan.org/), rstan (http://mc-stan.org/interfaces/rstan.html), rstanarm (http://mc-stan.org/users/interfaces/rstanarm.html) and Torsten (https://github.com/metrumresearchgroup/example-models) for Bayesian analysis of categorical, count and time-to-event data. Stan is a flexible open-source software tool for Bayesian data analysis using Hamiltonian Monte Carlo (HMC) simulation---a type of MCMC simulation. Torsten is a Stan extension containing a library of functions to simplify implementation of PKPD models. This workshop builds on the foundations presented in our previous introductory Stan workshops (http://metrumrg.com/events/2016/10/23/bayesianpkpd.html).…Find out more
This hands-on workshop will provide participants with a technical foundation for physiologically-based pharmacokinetic (PBPK) model development in R using mrgsolve, a free, open-source modeling and simulation platform for ODE-based model development in R (https://mrgsolve.github.io). The workshop gets started with an introduction to simulation with mrgsolve. We'll cover the essentials of a tidy simulation workflow in R. Then we'll jump into PBPK modeling with mrgsolve. After a brief introduction to principles of PBPK, we'll work through case studies using PBPK modeling.…Find out more
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