Physiologically-based pharmacokinetic model for predicting drug-drug interactions perpetrated by posaconazole in healthy subjects with normal weight and obesity: Concomitant use and washout

This study presents a validated whole-body PBPK model characterizing drug-drug interactions (DDIs) involving posaconazole, a broad-spectrum antifungal, in individuals with normal weight and obesity. Findings highlight a prolonged half-life and irreversible CYP3A4 inhibition in patients with BMI ≥35 kg/m², underscoring the increased risk of DDIs even after discontinuation. The model supports optimized dosing and risk assessment for co-administered CYP3A4-sensitive drugs.