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A showcase of open-source tools for scalable, reproducible PMx workflows

October 30, 2022 @ 12:00 pm - 5:00 pm

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Cost: Industry: $300 / Academia+Government: $200 / Student: $100

Join us for a half-day pre-meeting workshop at ACoP13!


  • Kyle Baron, PharmD, PhD
  • Sam Callisto, PhD
  • Seth Green, MS
  • Matthew Riggs, PhD

Learning Objectives

  • Identify the available open-source R packages developed by MetrumRG to support traceable, reproducible, and scalable pharmacometric analyses
  • Explore a reproducible pharmacometric analysis workflow

Topic Outline

  • Introduction to MetrumRG’s open-source R package ecosystem
    • Metrum Package Network (MPN) / pkgr: curated, reproducible R package environment 
    • bbi/bbr: a user-friendly interface between R and NONMEM® to manage, track, and report modeling activities through simple R objects  
    • yspec: data specifications, wrangling, and documentation
    • pmplots: exploratory and diagnostic plots for pharmacometrics
    • pmforest: forest plots, a visualization tool for identified variables of interest, for pharmacometrics
    • mrggsave: labeling, arranging, and saving figures
    • pmtables: tables for pharmacometrics including (i) built in functions to summarize data disposition and continuous or categorical variables, and (ii) simple functions to turn any dataframe/tibble into a highly customized tex table
    • lastdose: calculating last dose amount and time since previous doses 
  • Demonstration of individual R packages and how they support scalability and reproducibility during:
    • Project setup 
    • Data assembly
    • Data exploration
    • Model development and evaluation 
    • Simulation
    • Reporting
  • Resources for additional learning

To register, visit the ACoP meeting website.