In this tutorial session, we will review case studies in PBPK and QSP modeling and simulation using mrgsolve in R.  mrgsolve (https://mrgsolve.github.io) is a free, open-source modeling and simulation platform to support ODE-based model development in R.

Outline:

1. mrgsolve overview (brief tutorial)
2. PBPK model characterizing drug-drug interactions between HMG-CoA reductase inhibitors and cyclosporine (Yoshikado et al. 2016; PMID 27170342)
   1. Sensitivity analyses
   2. Parameter estimation
3. Evaluation of combination chemotherapy regimens using a QSP model for MAP kinase signaling in colorectal cancer (Kirouac et al. 2017; PMID 28649441)
   1. Create complicated input data sets
   2. Options for parallelizing simulations
4. Discussion

Names of Instructors: Kyle Baron Pharm.D., Ph.D., Matthew Riggs, Ph.D.

Materials Provided by Sponsor: Course slides, data and code for all examples.

Requirements for Attendees: Knowledge and experience in population PKPD modeling and a laptop with WiFi internet capability.