Steven Ernest, Ph.D.

Principal Scientist II

Steve joined Metrum in 2023 bringing over 20 years of experience in the pharmaceutical industry as a Pharmacometrician and Group Leader at Eli Lilly and Company. He attained his Ph.D. in Pharmacometrics from Uppsala University in 2013. He has applied PK/PD modeling, simulation and optimal design methods to support quantitative decision making across all phases of drug development and range of therapeutic areas and disease states.

Recent publications by this scientist

OptiDose with mrgsolve for efficacy and safety-driven dose optimization

September 16, 2025

Presented at ACCP Annual Meeting 2025. This work showcases the OptiDose method in mrgsolve, enabling efficient and systematic optimization of dosing regimens with respect to both efficacy and safety considerations. By optimizing across multiple clinical endpoints and patient preferences, these model-informed strategies can guide patient-centered dosing decisions in oncology.

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