Timothy Knab, Ph.D.

Science Advisor, Senior Scientist II

Tim joined Metrum in March 2017 after completing his Ph.D. in Chemical Engineering from the University of Pittsburgh where his dissertation was focused on modeling and controlling stress-induced hyperglycemia in critically ill patients. This work included dynamic optimization of models describing glucose-insulin dynamics and the development of model-predictive controllers and state estimators for clinical applications. Tim’s interests include the application of systems biology models to guide decision making in the drug development process and to advance treatment paradigms.

Recent publications by this scientist

Bayesian PBPK Modeling using R/Stan/Torsten and Julia/SciML/Turing.jl

January 23, 2023

Ahmed Elmokadem, Yi Zhang, Timothy Knab, William R. Gillespie. CPT Pharmacometrics Syst Pharmacol.  January, 20 2023. doi:10.1002/psp4.12926

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Bayesian PBPK Modeling using R/Stan/Torsten and Julia/SciML/Turing.jl

October 28, 2022

Ahmed Elmokadem, Yi Zhang, Tim Knab, Eric Jordie, William R. Gillespie. Poster presented at 2022 American Conference on Pharmacometrics (ACoP13). 30 October – November 2 2022. Poster W-074

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Landscape analysis for a neonatal disease progression model of bronchopulmonary dysplasia: Leveraging clinical trial experience and real-world data

October 25, 2022

Jeffrey S. Barrett, Megan Cala Pane, Timothy Knab, William Roddy, Jack Beusmans, Eric Jordie, Kanwaljit Singh, Jonathan Michael Davis, Klaus Romero, Michael Padula, Bernard Thebaud, Mark Turner. Front. Pharmacol. 2022 October 12. doi: 10.3389/fphar.2022.988974

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