Timothy Knab, Ph.D.

Science Advisor, Senior Scientist II

Tim joined Metrum in March 2017 after completing his Ph.D. in Chemical Engineering from the University of Pittsburgh where his dissertation was focused on modeling and controlling stress-induced hyperglycemia in critically ill patients. This work included dynamic optimization of models describing glucose-insulin dynamics and the development of model-predictive controllers and state estimators for clinical applications. Tim’s interests include the application of systems biology models to guide decision making in the drug development process and to advance treatment paradigms.

Recent publications by this scientist

A physiologically-based pharmacokinetic modeling approach to support candidate and first in human dose selection for bamlanivimab

September 3, 2021

Tim Knab, Ahmed Elmokadem, Emmanuel Chigutsa, Eric Jordie, Matthew Riggs, Patricia Brown-Augsburger, Christopher Wiethoff, Ajay Nirula, Jenny Y Chien, Lisa O’Brien.  Poster presented at Population Approach Group Europe Annual Meeting; 2-3 and 6-7 September 2021.  Poster I-64.

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Dosing regimen optimisation for oseltamivir in immunocompromised paediatric patients with influenza: Extrapolation of efficacy

August 27, 2021

Jordie EB, Gibiansky L, Knab T, Lemenuel-Diot A, Ravva P, Zwanziger E, Jolivet S, Bhardwaj R, Hernández-Sánchez J, Nasmyth-Miller C, Sturm S. Br J Clin Pharmacol. 2021;1-13. doi:10.1111/bcp.15059

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