Jimena Davis, Ph.D.

Senior Scientist I

Jimena joined MetrumRG in June 2023 as a Senior Scientist I. She earned her PhD in Applied and Computational Mathematics from North Carolina State University. She brings with her over 15 years of mathematical modeling and computational biology experience. Jimena spent 4 years at the US EPA as a Mathematical Statistician focused on uncertainty quantification of linked exposure-to-effects models for human health risk assessments. She then applied her mathematical modeling skills in various roles at Syngenta, including modeling biological pathways to support gene candidate discovery for plant traits and breeding in various crops. Jimena enjoys modeling complex biological systems to tackle challenges that humans face, and she’s looking forward to collaborating on solutions that will inform biomedical decisions in drug development programs.

Recent publications by this scientist

Quantitative Systems Pharmacology Model Predicts Combination Activity of CD19-targeted Loncastuximab Tesirine With Epcoritamab in B-cell Lymphoma

October 1, 2024

Presented at ACCP Annual Meeting 2024, this poster highlights a combination QSP model for Loncastuximab Tesirine and Epcoritamab in relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), predicting potential anti-tumor synergies in proposed clinical trials.

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Open-Science Immuno-Oncology QSP Modeling Using Open-Source Julia Solvers

July 28, 2023

As Julia usage continues to grow within regulated biomedical environments, it is vital to ensure analyses are traceable and reproducible. Conducting analyses in an open-science manner is also critical to expand the adoption of Julia and to facilitate the infrastructure growth of Julia as an accessible ecosystem. A step-by-step model-building example of a classic monoclonal antibody-drug conjugate PBPK/tumor dynamics system illustrates how to develop such a reproducible open-science framework.

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