James A. Rogers, Ph.D.

Principal Scientist II, Group Leader

Jim Rogers has over 15 years of experience as an applied statistician in the biomedical industry. He currently holds the title of Principal Scientist II at Metrum Research Group, where he leads a team of statistical modeling and simulation scientists. Prior to joining Metrum Research Group, Jim was an Associate Director of Statistics at Pfizer Global Research and Development, where he was the statistical lead on numerous clinical and preclinical projects in neuroscience. In 2008, Jim joined Metrum Research Group in order to work in closer collaboration with quantitative biologists and pharmacometricians. From a methodological perspective, Jim has been especially active in longitudinal modeling of constrained responses (e.g. cognitive rating scales in neuroscience), simulation-assisted design of dose-ranging trials and trials with adaptive features, and technologies for dynamic / interactive statistical support.

Recent publications by this scientist

Quantitative disease progression model of α-1 proteinase inhibitor therapy on computed tomography lung density in patients with α-1 antitrypsin deficiency

June 7, 2017

Tortorici MA, Rogers JA, Vit O, Bexon M, Sandhaus R A, Burdon J, Chorostowska-Wynimko J, Thompson P, Stocks J, McElvaney NG, Chapman KR, and Edelman JM. Br J Clin Pharmacol, June 2017.  doi: 10.1111/bcp.13358.

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Crenezumab exposure–response across AD endpoints supports a higher dose for phase 3

December 1, 2016

Polamus D, Rogers J, Paul R, Kshirsagar S, Sahasranaman S, Jin JY, Quartino AL.  Presented at the 9th Annual Clinical Trials on Alzheimer’s Disease (CTAD), December 2016.

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Dose-response and exposure-response modeling of alpha-1 proteinase inhibitor (A1-PI) in patients with A1-PI deficiency based on RAPID and RAPID extension trials

March 1, 2016

Rogers JA, Tortorici MA, Viti O, Brexon M, Sandhaus RA, Burdon J, Piitulainen E, Seersholm N, Stocks J, McElvaney NG, Chapman KR, Edelman JM.  Presented at the American Society for Clinical Pharmacology and Therapeutics (ASCPT) Annual Meeting, San Diego, CA, March 2016.

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